Compeed Blister Small hang Pck Blisters CAUSE : Excess friction and pressure cause the dermis and epidermis layers to loosen. A pocket is created which fills with lymph liquid. TREATMENT : Remove any loose skin, clean and dry the wound. APPLICATION : Remove the patterned protective layer, then remove the white protective paper and place the Compeed plaster directly over the blister. Gently pull away the non-touch tab. Handwarm the Compeed for one minute before and after application.